Clinicopathologic Implication of Ezrin Expression in Non-small Cell Lung Cancer
Korean Journal of Pathology
;
: 470-477, 2012.
Article
in English
| WPRIM
| ID: wpr-74041
ABSTRACT
BACKGROUND:
Ezrin, a member of the ezrin-radixin-moesin family, is implicated in tumor progression, metastatic dissemination, and adverse outcomes, in several cancer types. In this study, we explored the clinicopathological significance of ezrin expression in non-small cell lung carcinomas (NSCLCs).METHODS:
Immunohistochemical analysis of tissue microarray with 112 surgically resected NSCLC specimens, was performed to examine the ezrin expression. We also correlated ezrin expression with other clinicopathological features and prognosis.RESULTS:
The ezrin-positive group revealed significantly higher correlation with pleural invasion (p=0.016) and pathologic stage (p=0.050). Univariate survival analysis showed that ezrin-positive group had a significantly shorter cancer-specific survival than ezrin-negative group (p=0.016). Meanwhile, female (p=0.030), no pleural invasion (p=0.023), no lymphatic invasion (p=0.026), and early pathologic stage (p=0.008) significantly correlated with longer survival. Multivariate survival analysis showed that variables such as ezrin positivity (p=0.032), female (p=0.035), and early pathologic stage (p=0.001) were independent prognostic factors for NSCLC.CONCLUSIONS:
Ezrin might be a molecular marker to predict poor prognosis of NSCLC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Carcinoma, Non-Small-Cell Lung
/
Cytoskeletal Proteins
/
Lung
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2012
Type:
Article
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