Expression of Cortactin and Focal Adhesion Kinase in Colorectal Adenocarcinoma: Correlation with Clinicopathologic Parameters and Their Prognostic Implication
Korean Journal of Pathology
;
: 454-462, 2012.
Article
in English
| WPRIM
| ID: wpr-74043
ABSTRACT
BACKGROUND:
Cortactin and focal adhesion kinase (FAK) are two important components among actin cross-linking proteins that play a central role in cell migration.METHODS:
The aims of this study were to evaluate the expression of cortactin and FAK in normal colorectal mucosa and colorectal adenocarcinoma (CRC) using tissue microarray of 2 mm cores to correlate their expression with other clinicopathological factors and, investigate their prognostic significance.RESULTS:
Twenty (9%) and 24 cases (11%) of normal colorectal mucosa were immunoreactive for cortactin and FAK. In addition, 184 (84%) and 133 cases (61%) of CRCs were immunoreactive for cortactin and FAK, respectively. Cortactin expression was associated with histologic differentiation and FAK expression. Cortactin, but not FAK expression was also correlated with poor overall and relapse-free survival and served well as an independent prognostic factor for poor survival.CONCLUSIONS:
Cortactin expression, in association with FAK expression, may plays an important role in tumor progression. Furthermore, it may also be a satisfactory biomarker to predict tumor progression and survival in CRC patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Zinc Oxide
/
Calcium Hydroxide
/
Immunohistochemistry
/
Colorectal Neoplasms
/
Adenocarcinoma
/
Proteins
/
Actins
/
Focal Adhesions
/
Cortactin
/
Focal Adhesion Protein-Tyrosine Kinases
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2012
Type:
Article
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