Impact on Bisphosphonate Persistence and Compliance: Daily Postprandial Administration
Journal of Bone Metabolism
;
: 39-44, 2019.
Article
in English
| WPRIM
| ID: wpr-740476
ABSTRACT
BACKGROUND:
Bisphosphonate (BP) is an effective drug for the prevention and treatment of osteoporosis. However, gastrointestinal distress caused by BP is a well-known side effect for low compliance. The aim of our study was to compare the 1-year persistence, compliance and T-scores between the aperitif medication group and the postprandial medication group.METHODS:
Three hundred patients were included in this study to determine their persistence and compliance with the prescribed daily BP (Maxmarvil®, alendronate 5 mg and calcitriol 0.5 µg; YuYu Pharm) following distal radius fractures. Patients in Group 1 (aperitif medication) were asked to adhere to the general guidelines for BPs before breakfast. Patients in Group 2 (postprandial medication) were recommended medication after breakfast. We compared the persistence and compliance of this daily BP therapy using the medication possession ratio (MPR) and T-scores between the 2 groups after 1 year.RESULTS:
Bone mineral density in hip and lumbar spine was improved significantly in 2 groups (P < 0.001). Significant differences existed between 2 groups, including 73 of 150 patients (48.7%) in Group 1, and 111 of 150 patients (73.3%) in Group 2 for 1-year persistence (P=0.001). The mean MPR is 0.66 in Group 1 (range, 0.50–0.86) and 0.71 in Group 2 (range, 0.54–0.87). A significant difference was detected between the 2 groups (P=0.002).CONCLUSIONS:
Postprandial administration improved persistence and compliance with daily BP therapy, resulting in better clinical outcomes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoporosis
/
Radius Fractures
/
Spine
/
Calcitriol
/
Bone Density
/
Compliance
/
Alendronate
/
Breakfast
/
Hip
Type of study:
Practice guideline
Limits:
Humans
Language:
English
Journal:
Journal of Bone Metabolism
Year:
2019
Type:
Article
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