The Function of the Vitamin D Receptor and a Possible Role of Enhancer RNA in Epigenomic Regulation of Target Genes: Implications for Bone Metabolism
Journal of Bone Metabolism
;
: 3-12, 2019.
Article
in English
| WPRIM
| ID: wpr-740481
ABSTRACT
Vitamin D (VD) is essential for bone health, and VD or its analogues are widely used in clinics to ameliorate bone loss. The targets and mode of VD anti-osteoporotic actions appear to be different from those of other classes of drugs modulating bone remodeling. VD exerts its biological activities through the nuclear VD receptor (VDR)-mediated transcriptional regulation of target mRNA and non-coding RNA genes. VD-induced gene regulation involves epigenetic modifications of chromatin conformation at the target loci as well as reconfiguration of higher-order chromosomal organization through VDR-mediated recruitment of various regulatory factors. Enhancer RNAs (eRNA), a class of non-coding enhancer-derived RNAs, have recently emerged as VDR target gene candidates that act through reorganization of chromatin looping to induce enhancer-promoter interaction in activation of mRNA-encoding genes. This review outlines the molecular mechanisms of VD actions mediated by the VDR and suggests novel function of eRNAs in VDR transactivation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vitamin D
/
Vitamins
/
RNA
/
RNA, Messenger
/
Chromatin
/
Transcriptional Activation
/
Bone Remodeling
/
Receptors, Calcitriol
/
RNA, Untranslated
/
Epigenomics
Language:
English
Journal:
Journal of Bone Metabolism
Year:
2019
Type:
Article
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