Early Life Body Size in Relation to First Intracerebral or Subarachnoid Hemorrhage / 대한뇌졸중학회지
Journal of Stroke
;
: 60-68, 2019.
Article
in English
| WPRIM
| ID: wpr-740618
ABSTRACT
BACKGROUND AND PURPOSE:
As risk of hemorrhagic stroke may have early life origins, we investigated associations of birth weight and childhood body mass index (BMI) with adult intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH).METHODS:
We included 240,234 Danish schoolchildren, born 1936 to 1989, with information on birth weight and measured weights and heights from 7 to 13 years. We calculated hazard ratios (HRs) and confidence intervals (CIs) for the associations between early life anthropometrics and ICH or SAH, identified through linkage with national registers.RESULTS:
During the study period, 1,947 individuals (39% women) experienced an ICH and 797 individuals (64% women) experienced a SAH. Per 500 g increase in birth weight, women had a 10% decreased risk of SAH (HR, 0.90; 95% CI, 0.83 to 0.97) and men had a 10% decreased risk of ICH (HR, 0.90; 95% CI, 0.85 to 0.95). Birth weight was not associated with risks of ICH in women or SAH in men. In men, a childhood BMI below average (BMI z-score < 0) was associated with increased risks of ICH. The association was stronger at older childhood ages, and at 13 years a BMI z-score of –1 was associated with a HR of 1.17 (95% CI, 1.06 to 1.28), and a BMI z-score of –2 with a HR of 1.46 (95% CI, 1.17 to 1.82) for ICH. Childhood BMI was not associated with risks of ICH in women or with risks of SAH in both sexes.CONCLUSIONS:
Early life body size is associated with ICH and SAH, and the associations differ by sex.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Subarachnoid Hemorrhage
/
Weights and Measures
/
Birth Weight
/
Body Mass Index
/
Cerebral Hemorrhage
/
Cohort Studies
/
Stroke
/
Body Size
/
Origin of Life
/
Hemorrhage
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Stroke
Year:
2019
Type:
Article
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