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Abrupt Dyskeratotic and Squamoid Cells in Poorly Differentiated Carcinoma: Case Study of Two Thoracic NUT Midline Carcinomas with Cytohistologic Correlation
Journal of Pathology and Translational Medicine ; : 349-353, 2018.
Article in English | WPRIM | ID: wpr-741185
ABSTRACT
Cytologic diagnosis of nuclear protein in testis (NUT) midline carcinoma (NMC) is important due to its aggressive behavior and miserable prognosis. Early diagnosis of NMC can facilitate proper management, and here we report two rare cases of thoracic NMC with cytohistologic correlation. In aspiration cytology, the tumor presented with mixed cohesive clusters and dispersed single cells, diffuse background necrosis and many neutrophils. Most of the tumor cells had scanty cytoplasm and medium-sized irregular nuclei, which had fine to granular nuclear chromatin. Interestingly, a few dyskeratotic cells or squamoid cell clusters were present in each case. Biopsy specimen histology revealed more frequent squamous differentiation, and additional immunohistochemistry tests showed nuclear expression of NUT. Because this tumor has a notorious progression and has been previously underestimated in terms of its prevalence, awareness of characteristic findings and proper ancillary tests should be considered in all suspicious cases.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Testis / Biopsy / Immunohistochemistry / Nuclear Proteins / Chromatin / Prevalence / Cytoplasm / Early Diagnosis / Diagnosis Type of study: Diagnostic study / Prevalence study / Prognostic study / Screening study Language: English Journal: Journal of Pathology and Translational Medicine Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Testis / Biopsy / Immunohistochemistry / Nuclear Proteins / Chromatin / Prevalence / Cytoplasm / Early Diagnosis / Diagnosis Type of study: Diagnostic study / Prevalence study / Prognostic study / Screening study Language: English Journal: Journal of Pathology and Translational Medicine Year: 2018 Type: Article