TFE3-Expressing Perivascular Epithelioid Cell Tumor of the Breast
Journal of Pathology and Translational Medicine
;
: 62-65, 2019.
Article
in English
| WPRIM
| ID: wpr-741207
ABSTRACT
Perivascular epithelioid cell tumor (PEComa) is a very rare mesenchymal tumor with a distinctive morphology and immunophenotype. PEComas usually harbor TSC2 alterations, although TFE3 translocations, which occur in MiT family translocation renal cell carcinoma and alveolar soft part sarcoma, are also possible. We recently experienced a case of PEComa with TFE3 expression arising in the breast. An 18-year-old female patient presented with a right breast mass. Histologically, the tumor consisted of epithelioid cells with alveolar structure and showed a diffuse strong expression of HMB45 and TFE3. TSC2 was preserved. Melan A and smooth muscle actin were negative. To our knowledge, this is the first Korean case of PEComa of the breast that intriguingly presented with TFE3 expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast
/
Carcinoma, Renal Cell
/
Epithelioid Cells
/
Actins
/
Sarcoma, Alveolar Soft Part
/
Perivascular Epithelioid Cell Neoplasms
/
MART-1 Antigen
/
Muscle, Smooth
Limits:
Adolescent
/
Female
/
Humans
Language:
English
Journal:
Journal of Pathology and Translational Medicine
Year:
2019
Type:
Article
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