Quilty Lesions in the Endomyocardial Biopsies after Heart Transplantation
Journal of Pathology and Translational Medicine
;
: 50-56, 2019.
Article
in English
| WPRIM
| ID: wpr-741209
ABSTRACT
BACKGROUND:
The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients.METHODS:
A total of 1190 EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions, acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy was diagnosed by computed tomography coronary angiography. Clinical information, including the patients’ survival was retrieved by a review of medical records.RESULTS:
Eighty-eight patients (75.2%) were diagnosed with Quilty lesions, which were significantly associated with acute cellular rejection, but not with acute cellular rejection ≥ 2R or antibody-mediated rejection. In patient sdiagnosed with both Quilty lesions and acute cellular rejection, the time-to-onset of Quilty lesions from transplantation was longer than that of acute cellular rejections. We found a significant association between Quilty lesions and cardiac allograft vasculopathy. No significant relationship was found between Quilty lesions and the patients’ survival.CONCLUSIONS:
Quilty lesion may be an indicator of previous acute cellular rejection rather than a predictor for future acute cellular rejection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biopsy
/
Medical Records
/
Heart Transplantation
/
Coronary Angiography
/
Allografts
/
Heart
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Pathology and Translational Medicine
Year:
2019
Type:
Article
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