Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lung
Journal of Pathology and Translational Medicine
;
: 13-22, 2019.
Article
in English
| WPRIM
| ID: wpr-741213
ABSTRACT
BACKGROUND:
S100A8 and S100A9 have been gaining recognition for modulating tumor growthand metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 innon-small cell lung cancer (NSCLC).METHODS:
We analyzed the relationship between S100A8and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumorcells and peritumoral inflammatory cells.RESULTS:
The positive staining of S100A8 in tumorcells was significantly increased in male (p < .001), smoker (p = .034), surgical method other thanlobectomy (p = .024), squamous cell carcinoma (SQCC) (p < .001) and higher TNM stage (p = .022)compared with female, non-smoker, lobectomy, adenocarcinoma (ADC), and lower stage. Theproportion of tumor cells stained for S100A8 was related to histologic type (p < .001) and patientsex (p = .027). The proportion of inflammatory cells stained for S100A8 was correlated with patientage (p = .022), whereas the proportion of inflammatory cells stained for S100A9 was correlatedwith patient sex (p < .001) and smoking history (p = .031). Moreover, positive staining in tumorcells, more than 50% of the tumor cells stained and less than 30% of the inflammatory cellsstained for S100A8 and S100A9 suggested a tendency towards increased survivability in SQCCbut towards decreased survivability in ADC.CONCLUSIONS:
S100A8 and S100A9 expressions might be potential prognostic markers in patients with NSCLC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Smoke
/
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Smoking
/
Carcinoma, Non-Small-Cell Lung
/
Calgranulin B
/
Lung
/
Lung Neoplasms
/
Methods
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Pathology and Translational Medicine
Year:
2019
Type:
Article
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