Diagnostic accuracy of urinary biomarkers in infants younger than 3 months with urinary tract infection / 소아과
Korean Journal of Pediatrics
;
: 24-29, 2018.
Article
in English
| WPRIM
| ID: wpr-741351
ABSTRACT
PURPOSE:
The aim of this study was to evaluate the diagnostic accuracy of urinary biomarkers, such as neutrophil gelatinase-associated lipocalin (uNGAL) and β-2 microglobulin (uB2MG), in early detection of urinary tract infection (UTI) in infants aged < 3 months with fever.METHODS:
A total of 422 infants aged < 3 months (malefemale=267155; mean age, 56.4 days), who were admitted for fever, were retrospectively included in this study. We compared uNGAL and uB2MG between the UTI and non-UTI groups at the time of admission. The sensitivity, specificity, accuracy, and area under the curve (AUC) of uNGAL and uB2MG for use in diagnosing UTI were assessed.RESULTS:
Among 422 patients, 102 (24.2%) were diagnosed with UTI. Levels of uNGAL were higher in the UTI group than in the non-UTI group (366.6 ng/mL vs. 26.9 ng/mL, P < 0.001). Levels of uB2MG were not different between the 2 groups. Multivariate analysis revealed that uNGAL was an independent predictive factor for UTI (P=0.033). The sensitivity, specificity, and accuracy were 90.2%, 92.5%, and 91.9% for uNGAL, and 48.0%, 43.8%, and 44.8% for uB2MG, respectively. AUC of uNGAL was 0.942 and that of uB2MG was 0.407.CONCLUSION:
Accuracy of uNGAL in the diagnosis of UTI is high in febrile infants aged < 3 months. uNGAL can help in the early diagnosis and treatment of UTI in infants.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urinary Tract
/
Urinary Tract Infections
/
Biomarkers
/
Multivariate Analysis
/
Retrospective Studies
/
Sensitivity and Specificity
/
Area Under Curve
/
Early Diagnosis
/
Diagnosis
/
Lipocalins
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Screening study
Limits:
Humans
/
Infant
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2018
Type:
Article
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