Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging
Korean Journal of Radiology
;
: 830-843, 2019.
Article
in English
| WPRIM
| ID: wpr-741449
ABSTRACT
OBJECTIVE:
To examine the potential of intravoxel incoherent motion (IVIM) and blood oxygen level-dependent (BOLD) magnetic resonance imaging for detecting renal changes after iodinated contrast-induced acute kidney injury (CI-AKI) development in a diabetic rabbit model. MATERIALS ANDMETHODS:
Sixty-two rabbits were randomized into 2 groups diabetic rabbits with the contrast agent (DCA) and healthy rabbits with the contrast agent (NCA). In each group, 6 rabbits underwent IVIM and BOLD imaging at 1 hour, 1 day, 2 days, 3 days, and 4 days after an iohexol injection while 5 rabbits were selected to undergo blood and histological examinations at these specific time points. Iohexol was administrated at a dose of 2.5 g I/kg of body weight. Further, the apparent transverse relaxation rate (R2*), average pure molecular diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) were calculated.RESULTS:
The D and f values of the renal cortex (CO) and outer medulla (OM) were significantly decreased compared to baseline values in the 2 groups 1 day after the iohexol injection (p < 0.05). A marked reduction in the D* values for both the CO and OM was also observed after 1 hour in each group (p < 0.05). In the OM, a persistent elevation of the R2* was detected for 4 days in the DCA group (p < 0.05). Histopathological changes were prominent, and the pathological features of CI-AKI aggravated in the DCA group until day 4. The D, f, and R2* values significantly correlated with the histological damage scores, hypoxia-inducible transcription factor-1α expression scores, and serum creatinine levels.CONCLUSION:
A combination of IVIM and BOLD imaging may serve as a noninvasive method for detecting and monitoring CI-AKI in the early stages in the diabetic kidney.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Perfusion
/
Relaxation
/
Body Weight
/
Iohexol
/
Magnetic Resonance Imaging
/
Creatinine
/
Vascular Endothelial Growth Factor A
/
Diffusion
/
Acute Kidney Injury
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Korean Journal of Radiology
Year:
2019
Type:
Article
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