Circulating Levels of Interleukin-6 and Soluble Interleukin-6 Receptor in Acute Asthma / 결핵
Tuberculosis and Respiratory Diseases
;
: 464-470, 2000.
Article
in Korean
| WPRIM
| ID: wpr-74147
ABSTRACT
BACKGROUND:
The recognition of bronchial asthma as an inflammatory disease led to a search for soluble markers that would be useful in assessing airway inflammation. Interleukin-6 (IL-6) is a representative proinflammatory cytokine that has been shown to be connected with various inflammatory diseases. IL-6 acts via specific receptors that consist of the IL-6 binding glycoprotein gp80 and the signal transducer gp130. In the search for markers of airway inflammation, we investigated the role of soluble interleukin-6 receptor (sIL-6R) and IL-6 in acute asthma.METHODS:
Serum levels of sIL-6R and IL-6 were measured in 78 acute asthmatics, in 15 patients with asymptomatic asthma and in 10 healthy control subjects by a specific ELISA using a murine antihuman IL-6R, IL-6 mAb (Quantikine sIL-6R, IL-6).RESULTS:
Serum levels of IL-6 in acute asthmatics significantly exeeded those of control subjects. Those of sIL-6R in acute asthmatics were also significantly increased compared to those of control subjects. The serum concentration of IL-6 obtained in acute asthmatics was elevated as compared with the asymptomatic asthmatics. However, Association between eosinophilic count / IgE and IL-6 / sIL-6R in acute asthma could not found.CONCLUSION:
Our results suggest that IL-6 may be involved in the pathogenesis of acute asthma and serum levels of IL-6 and sIL-6R may reflect the severity of airway inflammation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Immunoglobulin E
/
Enzyme-Linked Immunosorbent Assay
/
Glycoproteins
/
Interleukin-6
/
Eosinophils
/
Cytokine Receptor gp130
/
Inflammation
Limits:
Humans
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2000
Type:
Article
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