Different invasion efficiencies of Brucella abortus wild-type and mutantsin RAW 264.7 and THP-1 phagocytic cells and HeLa non-phagocytic cells / 대한수의학회지
Korean Journal of Veterinary Research
;
: 95-98, 2018.
Article
in English
| WPRIM
| ID: wpr-741500
ABSTRACT
Brucellosis is one of the common zoonoses caused by Brucella abortus (B. abortus). However, little has been reported on factors affecting invasion of B. abortus into host cells. To investigate cell-type dependent invasion of B. abortus, phagocytic RAW 264.7 and THP-1 cells and non-phagocytic HeLa cells were infected with wild-type and mutant B. abortus, and their invasion efficiencies were compared. The invasion efficiencies of the strains were cell-type dependent. Wild-type B. abortus invasion efficiency was greater in phagocytic cells than in epithelial cells. The results also indicated that there are different factors involved in the invasion of B. abortus into phagocytic cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phagocytes
/
Brucella
/
Brucella abortus
/
Brucellosis
/
HeLa Cells
/
Zoonoses
/
Epithelial Cells
Limits:
Humans
Language:
English
Journal:
Korean Journal of Veterinary Research
Year:
2018
Type:
Article
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