Molecular Epidemiology of Mycobacterium leprae as Determined by Structure-Neighbor Clustering in Korea found cases / 나학회지
Korean Leprosy Bulletin
;
: 25-42, 2017.
Article
in Korean
| WPRIM
| ID: wpr-741535
ABSTRACT
BACKGROUND:
It has proven challenging to investigate the molecular epidemiology of Mycobacterium leprae, the causative agent of leprosy, due to difficulties with culturing of the organism and a lack of genetic heterogeneity between strains. Recently, A panel of variable-number tandem-repeat (VNTR) markers and an alternative method, structure-neighbor clustering, which assigns isolates with the most similar genotypes to the same groups and, subsequently, subgroups, without inferring how the strains descended from a common ancestor have been developed.METHODS:
A total of 29 samples from Korea found cases were studied by 14 VTRN typing and an alternative method, structure-neighbor clustering with 13 and 14 VNTRs by Structure Program(k=10).RESULTS:
Only 286 cases of 522 total cases(including database of Bellingham Research Institute) showed p>0.8(in 13 and 14 VNTRs). Almost Korea found cases(18 cases) were included in group 3(13 VNTRs), in group 9(14 VNTRs)(by Structure Program, k=10).CONCLUSIONS:
The structure-neighbor clustering by Structure Program with panels of VNTR is a useful approach for investigating the molecular epidemiology of Mycobacterium leprae.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cluster Analysis
/
Molecular Epidemiology
/
Genetic Heterogeneity
/
Genotype
/
Korea
/
Leprosy
/
Methods
/
Mycobacterium
/
Mycobacterium leprae
Type of study:
Screening study
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Leprosy Bulletin
Year:
2017
Type:
Article
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