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Simultaneous Determination of Four Compounds from Artemisia capillaris using High Performance Liquid Chromatography-Ultraviolet Detector (HPLC-UVD) and Their Quantitative Study in Artemisia Genus
Natural Product Sciences ; : 109-114, 2018.
Article in English | WPRIM | ID: wpr-741608
ABSTRACT
Artemisia capillaris Thunb. (Compositae) is a native herb of East Asian countries and has used for the treatment of jaundice, high liver fever, and digestive diseases for a long time, as well as being developed as the source of herbal preparations until now. The major components from A. capillaris were chlorogenic acid (1) and its derivatives substituted with caffeoyl moieties, such as 3,5-dicaffeoylquinic acid (2) and 4,5-dicaffeoylquinic acid (3), and coumarins, such as scoparone. In the study, four compounds, chlorogenic acid, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid and scoparone (4) in the 70% ethanolic extract of A. capillaris were simultaneously determined by using HPLC-UVD system. This method was validated with the terms of linearity, precious and accuracy according to ICH guidelines. The developed method was successfully applied for the quantitative analysis of Artemisia genus, A. capillaris, A. iwayomogi, A. princeps, and A. argyi, distributed in Korea.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Chlorogenic Acid / Artemisia / Coumarins / Plant Preparations / Asian People / Ethanol / Fever / Jaundice / Korea / Liver Type of study: Practice guideline Limits: Humans Country/Region as subject: Asia Language: English Journal: Natural Product Sciences Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Chlorogenic Acid / Artemisia / Coumarins / Plant Preparations / Asian People / Ethanol / Fever / Jaundice / Korea / Liver Type of study: Practice guideline Limits: Humans Country/Region as subject: Asia Language: English Journal: Natural Product Sciences Year: 2018 Type: Article