Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells
Natural Product Sciences
;
: 99-102, 2018.
Article
in English
| WPRIM
| ID: wpr-741610
ABSTRACT
This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and 10 µM increased intracellular dopamine levels at 1 – 24 h. Ombuoside (1, 5, and 10 µM) also significantly increased the phosphorylation of tyrosine hydroxylase (TH) (Ser40) and cyclic AMP-response element binding protein (CREB) (Ser133) at 0.5 – 6 h. In addition, ombuoside (1, 5, and 10 µM) combined with L-DOPA (20, 100, and 200 µM) further increased intracellular dopamine levels for 24 h compared to L-DOPA alone. These results suggest that ombuoside regulates dopamine biosynthesis by modulating TH and CREB activation in PC12 cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Tyrosine 3-Monooxygenase
/
Carrier Proteins
/
Dopamine
/
Levodopa
/
PC12 Cells
Limits:
Animals
Language:
English
Journal:
Natural Product Sciences
Year:
2018
Type:
Article
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