Cytotoxic Triterpenoids from the Fruits of Ligustrum japonicum
Natural Product Sciences
;
: 93-98, 2018.
Article
in English
| WPRIM
| ID: wpr-741611
ABSTRACT
Medicinal plants are potential sources of anticancer agents screening. A large number of phytochemicals, including triterpenoids, have been reported to have significant cytotoxic effects on cancer cells. From the fruits of Ligustrum japonicum Thunb., thirteen triterpenoids (1 – 13) were isolated and evaluated for their cytotoxic activity against Hela and HL-60 cells. As results, 8 (oleanolic acid) showed significant effects on Hela with IC50 values of 5.5 µM, and moderate effects on HL-60 cells with IC₅₀ values of 55.9 µM. Meanwhile, 10 (oleanderic acid) and 11 (3β-acetoxy-urs-12-en-28-oic acid) exhibited moderate inhibitory effects on Hela with IC₅₀ value of 55.0 and 68.8 µM, respectively. Moreover, 10 showed cytotoxic effect on HL-60 cell line with IC₅₀ value of 63.9 µM. To our knowledge, this is the first report that oleanderic acid was isolated from L. japonicum and investigated in cytotoxic effects on Hela and HL-60 cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Mass Screening
/
HL-60 Cells
/
Inhibitory Concentration 50
/
Nerium
/
Oleaceae
/
Ligustrum
/
Phytochemicals
/
Fruit
/
Antineoplastic Agents
Type of study:
Screening study
Limits:
Humans
Language:
English
Journal:
Natural Product Sciences
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS