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Cytotoxic Triterpenoids from the Fruits of Ligustrum japonicum
Natural Product Sciences ; : 93-98, 2018.
Article in English | WPRIM | ID: wpr-741611
ABSTRACT
Medicinal plants are potential sources of anticancer agents screening. A large number of phytochemicals, including triterpenoids, have been reported to have significant cytotoxic effects on cancer cells. From the fruits of Ligustrum japonicum Thunb., thirteen triterpenoids (1 – 13) were isolated and evaluated for their cytotoxic activity against Hela and HL-60 cells. As results, 8 (oleanolic acid) showed significant effects on Hela with IC50 values of 5.5 µM, and moderate effects on HL-60 cells with IC₅₀ values of 55.9 µM. Meanwhile, 10 (oleanderic acid) and 11 (3β-acetoxy-urs-12-en-28-oic acid) exhibited moderate inhibitory effects on Hela with IC₅₀ value of 55.0 and 68.8 µM, respectively. Moreover, 10 showed cytotoxic effect on HL-60 cell line with IC₅₀ value of 63.9 µM. To our knowledge, this is the first report that oleanderic acid was isolated from L. japonicum and investigated in cytotoxic effects on Hela and HL-60 cells.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Mass Screening / HL-60 Cells / Inhibitory Concentration 50 / Nerium / Oleaceae / Ligustrum / Phytochemicals / Fruit / Antineoplastic Agents Type of study: Screening study Limits: Humans Language: English Journal: Natural Product Sciences Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Mass Screening / HL-60 Cells / Inhibitory Concentration 50 / Nerium / Oleaceae / Ligustrum / Phytochemicals / Fruit / Antineoplastic Agents Type of study: Screening study Limits: Humans Language: English Journal: Natural Product Sciences Year: 2018 Type: Article