Cytotoxic Constituents from the Roots of Asarum sieboldii in Human Breast Cancer Cells
Natural Product Sciences
;
: 72-75, 2019.
Article
in English
| WPRIM
| ID: wpr-741641
ABSTRACT
Bioassay-guided fractionation of the roots of Asarum sieboldii led to the isolation of the six compounds methylkakuol (1), sesamin (2), asarinin (3), xanthoxylol (4), and (2E,4E,8Z,10E/Z)-N-(2-methylpropyl) dodeca-2,4,8,10-tetraenamide (5/6). Among the isolates, xanthoxylol (4) exhibited significant cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with IC₅₀ values of 9.15 and 13.95 µM, respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
In Vitro Techniques
/
Breast
/
Breast Neoplasms
/
Asarum
Limits:
Humans
Language:
English
Journal:
Natural Product Sciences
Year:
2019
Type:
Article
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