Isolation of Constituents with Nitric Oxide Synthase Inhibition Activity from Phryma leptostachya var. asiatica
Natural Product Sciences
; : 34-37, 2019.
Article
in En
| WPRIM
| ID: wpr-741647
Responsible library:
WPRO
ABSTRACT
Phytochemical studies were performed to identify the active principles of Phryma leptostachya var. asiatica (Phyrymaceae) for anti-inflammation. The anti-inflammatory activity was assessed by measuring the inhibition rate on nitric oxide (NO) formation in lipopolysaccharide (LPS)-activated macrophage 264.7 cells. Of the five compounds including ursolic acid, phrymarolin I, harpagide, haedoxancoside A, and acteoside isolated from this plant, ursolic acid showed the most prominent inhibition of NO formation. Therefore, ursolic acid may be the anti-inflammatory principle of Phryma leptostachya var. asiatica.
Key words
Full text:
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Index:
WPRIM
Main subject:
Plants
/
Nitric Oxide Synthase
/
Macrophages
/
Nitric Oxide
Language:
En
Journal:
Natural Product Sciences
Year:
2019
Type:
Article