Comparison of Clinical Factors and Neurodevelopmental Outcomes between Early- and Late-Onset Periventricular Leukomalacia in Very Low Birth Weight Infants
Neonatal Medicine
;
: 48-54, 2019.
Article
in Korean
| WPRIM
| ID: wpr-741664
ABSTRACT
PURPOSE:
To analyze and compare the clinical factors and neurodevelopmental outcomes compare early- and late-onset periventricular leukomalacia (PVL) in very low birth weight infants (VLBWI).METHODS:
We performed a retrospective study involving 199 newborn infants weighing < 1,500 g admitted to the neonatal intensive care unit between March 2009 and December 2015. VLBWI with PVL were categorized into early- and late-onset PVL groups based on the time of diagnosis based on 28 days of age. We analyzed the clinical factors and neurodevelopmental outcomes between the groups.RESULTS:
The incidence rate of PVL was 10.1% (16/158). The Apgar score at 1 minute and the mean duration of tocolytic therapy were associated with the development of PVL. The incidence rate of premature rupture of membranes (PROM) was significantly higher in the early-onset PVL group (P=0.041). No significant differences were observed in neurodevelopmental outcomes between the early- and late-onset PVL groups.CONCLUSION:
Results suggest that a higher incidence of PROM was associated with clinical characteristics in the early-onset PVL group. No significant intergroup differences were observed in neurodevelopmental outcomes; however, the Bayley Scales of Infant Development-III scores were lower in the early-onset PVL group.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apgar Score
/
Rupture
/
Weights and Measures
/
Leukomalacia, Periventricular
/
Fetal Membranes, Premature Rupture
/
Tocolysis
/
Intensive Care, Neonatal
/
Incidence
/
Retrospective Studies
/
Infant, Very Low Birth Weight
Type of study:
Diagnostic study
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Infant
/
Infant, Newborn
/
Pregnancy
Language:
Korean
Journal:
Neonatal Medicine
Year:
2019
Type:
Article
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