Treatment of Children and Adolescents with Attention Deficit Hyperactivity Disorder and/or Tourette's Disorder with Clonidine Extended Release
Psychiatry Investigation
;
: 90-93, 2018.
Article
in English
| WPRIM
| ID: wpr-741879
ABSTRACT
We aimed to assess the effectiveness and safety of clonidine extended release (ER) treatment in Korean youth with ADHD and/or Tourette's disorder. We retrospectively reviewed the medical records of 29 children and adolescents treated with clonidine ER. The effectiveness were retrospectively measured at baseline and after 4 and 12 weeks based on the Clinical Global Impression-Severity (CGI-S) and Clinical Global Impression-Improvement (CGI-I) scores. Safety was evaluated at each visit based on spontaneous reports from the subjects or from their parents/guardians. Significant decreases in the CGI-S scores for both ADHD (F=23.478, p < 0.001, partial η2=0.540) and tic symptoms (F=15.137, p < 0.001, partial η2=0.443) were noted over 12 weeks. The most common adverse event was somnolence (n=9, 31.0%) and life-threatening adverse effects were not observed. Our results provide preliminary evidence for the effectiveness and safety of clonidine ER.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Attention Deficit Disorder with Hyperactivity
/
Tourette Syndrome
/
Medical Records
/
Retrospective Studies
/
Clonidine
/
Tics
Type of study:
Observational study
Limits:
Adolescent
/
Child
/
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2018
Type:
Article
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