Dosimetric comparison of IMRT versus 3DCRT for post-mastectomy chest wall irradiation
Radiation Oncology Journal
;
: 71-78, 2018.
Article
in English
| WPRIM
| ID: wpr-741926
ABSTRACT
PURPOSE:
To compare the dose distribution of three-dimensional conformal radiation therapy (3DCRT) with intensity-modulated radiation therapy (IMRT) for post-mastectomy radiotherapy (PMRT) to left chest wall. MATERIALS ANDMETHODS:
One hundred and seven patients were randomised for PMRT in 3DCRT group (n = 64) and IMRT group (n = 43). All patients received 50 Gy in 25 fractions. Planning target volume (PTV) parameters—Dnear-max (D2), Dnear-min (D98), Dmean, V95, and V107—homogeneity index (HI), and conformity index (CI) were compared. The mean doses of lung and heart, percentage volume of ipsilateral lung receiving 5 Gy (V5), 20 Gy (V20), and 55 Gy (V55) and that of heart receiving 5 Gy (V5), 25 Gy (V25), and 45 Gy (V45) were extracted from dose-volume histograms and compared.RESULTS:
PTV parameters were comparable between the two groups. CI was significantly improved with IMRT (1.127 vs. 1.254, p < 0.001) but HI was similar (0.094 vs. 0.096, p = 0.83) compared to 3DCRT. IMRT in comparison to 3DCRT significantly reduced the high-dose volumes of lung (V20, 22.09% vs. 30.16%; V55, 5.16% vs. 10.27%; p < 0.001) and heart (V25, 4.59% vs. 9.19%; V45, 1.85% vs. 7.09%; p < 0.001); mean dose of lung and heart (11.39 vs. 14.22 Gy and 4.57 vs. 8.96 Gy, respectively; p < 0.001) but not the low-dose volume (V5 lung, 61.48% vs. 51.05%; V5 heart, 31.02% vs. 23.27%; p < 0.001).CONCLUSIONS:
For left sided breast cancer, IMRT significantly improves the conformity of plan and reduce the mean dose and high-dose volumes of ipsilateral lung and heart compared to 3DCRT, but 3DCRT is superior in terms of low-dose volume.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiometry
/
Radiotherapy
/
Thorax
/
Breast Neoplasms
/
Mastectomy, Modified Radical
/
Thoracic Wall
/
Radiotherapy, Intensity-Modulated
/
Unilateral Breast Neoplasms
/
Heart
/
Lung
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Radiation Oncology Journal
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS