Histopathology of gastric mucous membrane in patients with duodenal ulcer before and after treatment with Che day (Ampelopsis Cantoniensis Planch)

ABSTRACT

Introduction: Che day (Ampelopsis Cantoniensis Planch) is a medicinal herb that has been used for a long time in Vietnamese Traditional Medicine for treating gastroduodenal ulcer. Scientific studies found that Che day has some chemical components such as flavonoids, tannins and uronic compounds that can neutralize the gastric acidity. Objectives: This study was conducted with the aim of evaluating the H pylori eradication ability and the anti-inflammation properties of Che day for duodenal ulcer, using histopathological measures. Subjects and method: 43 patients with endoscopy-confirmed diagnosis of duodenal ulcer were involved in the opening clinical trial. Ages of patients were ranged from 18 to 65 years old. The patients were treated for 6 weeks by dried extracts of Che day (four 5gr-sachets divided into 4 times a day) and underwent endoscopic biopsy before and post-treatment. Results: Che day had the HP eradication effect in 17/43 patients (42.5%), as seen in histophathological examinations. This results were significant with p <0.001. The rate of recovering patients reached up to 23.26% (10/43 patients) and the rate of severe cases reduced dramatically (18/20 patients). The comparison before and after 6 weeks of treatment showed the prevention effect of Che day from gastritis with statistic significance (p<0.001). Conclusion: Che day has the HP eradication ability with the rate reaching up to 42.5%. This herb reduced the gastritis in histopathological studies. 23.26% of patients recovered from duodenal ulcer after treatment and the severe cases were dramatically reduced.