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Prognostic Implications of Postoperative Infectious Complications in Non-Small Cell Lung Cancer / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery ; : 41-52, 2018.
Article in English | WPRIM | ID: wpr-742322
ABSTRACT

BACKGROUND:

Few studies have evaluated the long-term impact of postoperative infectious complications in patients with non-small cell lung cancer (NSCLC). We aimed to determine the impact of infectious complications on long-term outcomes after surgical resection for NSCLC.

METHODS:

We performed a retrospective study of 1,380 eligible patients who underwent pulmonary resection for NSCLC from 2003 to 2012. Complications were divided into infectious complications and non-infectious complications. Kaplan-Meier survival analysis was used to compare unadjusted 5-year cancer-specific survival (CSS) rates and recurrence-free survival (RFS) rates. Cox regression was used to determine the impact of infectious complications on 5-year CSS and RFS.

RESULTS:

The rate of total complications and infectious complications was 24.3% and 4.3%, respectively. In the node-negative subgroup, the 5-year CSS and RFS rates were 75.9% and 57.1% in patients who had infectious complications, compared to 87.9% and 78.4% in patients who had no complications. Infectious complications were a negative prognostic factor for 5-year RFS (hazard ratio, 1.92; 95% confidence interval, 1.00–3.69; p=0.049). In the node-positive subgroup, the 5-year CSS rate and RFS were 44.6% and 48.4% in patients who had infectious complications, compared to 70.5% and 48.4% for patients who had no complications.

CONCLUSION:

Postoperative infectious complications had a negative impact on CSS and RFS in node-negative NSCLC. Our findings may help improve risk assessment for tumor recurrence after pulmonary resection for node-negative NSCLC.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Recurrence / Retrospective Studies / Carcinoma, Non-Small-Cell Lung / Risk Assessment Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: The Korean Journal of Thoracic and Cardiovascular Surgery Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Recurrence / Retrospective Studies / Carcinoma, Non-Small-Cell Lung / Risk Assessment Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: The Korean Journal of Thoracic and Cardiovascular Surgery Year: 2018 Type: Article