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Outcomes of the Multimodal Treatment of Malignant Pleural Mesiothelioma: The Role of Surgery / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery ; : 35-40, 2018.
Article in English | WPRIM | ID: wpr-742323
ABSTRACT

BACKGROUND:

The treatment of malignant pleural mesothelioma (MPM) is challenging, and multimodal treatment including surgery is recommended; however, the role of surgery is debated. The treatment outcomes of MPM in Korea have not been reported. We analyzed the outcomes of MPM in the context of multimodal treatment, including surgery.

METHODS:

The records of 29 patients with pathologically proven MPM from April 1998 to July 2015 were retrospectively reviewed. The treatment outcomes of the surgery and non-surgery groups were compared.

RESULTS:

The overall median survival time was 10.6 months, and the overall 3-year survival rate was 25%. No postoperative 30-day or in-hospital mortality occurred in the surgery group. Postoperative complications included tachyarrhythmia (n=4), pulmonary thromboembolism (n=1), pneumonia (n=1), chylothorax (n=1), and wound complications (n=3). The treatment outcomes between the surgery and non-surgery groups were not significantly different (3-year survival rate 31.3% vs. 16.7%, respectively; p=0.47). In a subgroup analysis, there was no significant difference in the treatment outcomes between the extrapleural pneumonectomy group and the non-surgery group (3-year survival rate 45.5% vs. 16.7%, respectively; p=0.23).

CONCLUSION:

Multimodal treatment incorporating surgery did not show better outcomes than non-surgical treatment. A nationwide multicenter data registry and prospective randomized controlled studies are necessary to optimize the treatment of MPM.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumonectomy / Pneumonia / Postoperative Complications / Prognosis / Pulmonary Embolism / Tachycardia / Wounds and Injuries / Survival Rate / Prospective Studies / Retrospective Studies Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: The Korean Journal of Thoracic and Cardiovascular Surgery Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumonectomy / Pneumonia / Postoperative Complications / Prognosis / Pulmonary Embolism / Tachycardia / Wounds and Injuries / Survival Rate / Prospective Studies / Retrospective Studies Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: The Korean Journal of Thoracic and Cardiovascular Surgery Year: 2018 Type: Article