Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats
The World Journal of Men's Health
;
: 249-256, 2019.
Article
in English
| WPRIM
| ID: wpr-742352
ABSTRACT
PURPOSE:
To investigate the effects of all-trans retinoic acid (ATRA) in cisplatin (CP)-induced testicular damage in rats. MATERIALS ANDMETHODS:
Twenty-eight male Wistar rats were divided into four groups Control, ATRA alone, ATRA+CP, and CP alone. Body weight, testicular weight, sperm count, sperm motility, percentage of abnormal sperm, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) in testicular tissue, and testicular histopathology were compared among groups.RESULTS:
The sperm count and motility significantly decreased and the percentage of abnormal sperm significantly increased in the CP group compared to the control and ATRA groups. CP+ATRA administration significantly increased the sperm count and motility, but reduced the abnormal sperm count. CP administration significantly increased TOS and OSI compared to the control group and the other groups. Administering CP+ATRA significantly decreased TOS and the OSI in testicular tissue and reduced spermatogenesis, but increased the Johnsen score.CONCLUSIONS:
The destructive effects of CP treatment on testicular tissue and spermatogenesis were reduced by administering ATRA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sperm Count
/
Sperm Motility
/
Spermatogenesis
/
Spermatozoa
/
Testis
/
Tretinoin
/
Vitamin A
/
Body Weight
/
Cisplatin
/
Rats, Wistar
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
The World Journal of Men's Health
Year:
2019
Type:
Article
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