Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques
The World Journal of Men's Health
;
: 148-156, 2019.
Article
in English
| WPRIM
| ID: wpr-742363
ABSTRACT
During the last decades the study of male infertility and the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict fertilization. Sperm genetic components could play an important role in the early stages of embryonic development. Based on these acquisitions, several epigenetic investigations have been developed on spermatozoa, with the aim of understanding the multifactorial etiology of male infertility and of showing whether embryonic development may be influenced by sperm epigenetic abnormalities. This article reviews the possible epigenetic modifications of spermatozoa and their effects on male fertility, embryonic development and ART outcome. It focuses mainly on sperm DNA methylation, chromatin remodeling, histone modifications and RNAs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spermatozoa
/
RNA
/
DNA Methylation
/
Reproductive Techniques, Assisted
/
Chromatin Assembly and Disassembly
/
Histone Code
/
Embryonic Development
/
Fertility
/
Fertilization
/
Epigenomics
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
/
Pregnancy
Language:
English
Journal:
The World Journal of Men's Health
Year:
2019
Type:
Article
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