Pharmacodynamic principles and the time course of delayed and cumulative drug effects
Translational and Clinical Pharmacology
;
: 56-59, 2018.
Article
in English
| WPRIM
| ID: wpr-742406
ABSTRACT
This tutorial reviews the principles of the concentration — effect relationship for the usual case when drug effects are delayed relative to changes in circulating concentrations. The key processes determining delay are distribution from the circulation to the receptor, binding to the receptor to produce a stimulus and translation of the receptor stimulus into an effect through turnover of physiological mediators. Some clinical outcomes are dependent on the accumulation of drug action which is predictable in terms of basic pharmacokinetic and pharmacodynamic concepts.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dose-Response Relationship, Drug
/
Models, Biological
Type of study:
Prognostic study
Language:
English
Journal:
Translational and Clinical Pharmacology
Year:
2018
Type:
Article
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