Clinical Outcomes of Low-Dose Methotrexate Therapy as a Second-Line Drug for Intravenous Immunoglobulin-Resistant Kawasaki Disease
Yonsei Medical Journal
; : 113-118, 2018.
Article
in En
| WPRIM
| ID: wpr-742496
Responsible library:
WPRO
ABSTRACT
PURPOSE: Intravenous immunoglobulin (IVIG) is the standard treatment for Kawasaki disease (KD). However, there is still no standard treatment for IVIG-resistant KD. This study aimed to evaluate the efficacy of low-dose methotrexate (MTX) as a treatment for IVIG-resistant KD. MATERIALS AND METHODS: We retrospectively analyzed 10-year data for patients with IVIG-resistant KD who were administered MTX at Severance Children's Hospital. RESULTS: The subjects included 75 patients with KD aged 5 months to 9.2 years who had been administered MTX. Their maximum body temperatures decreased significantly within 24 h of therapy. The patients' C-reactive protein levels were significantly lower 1 week after administering the first dose of MTX than those before treatment. No adverse effect for MTX was observed. CONCLUSION: MTX treatment of IVIG-resistant KD resulted in rapid defervescence, improvement of clinical symptoms, and normalization of acute-phase reactants in all patients. Thus, MTX could be a candidate treatment for IVIG-resistant KD.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Steroids
/
C-Reactive Protein
/
Demography
/
Methotrexate
/
Retrospective Studies
/
Treatment Outcome
/
Immunoglobulins, Intravenous
/
Coronary Vessels
/
Dose-Response Relationship, Drug
/
Drug Therapy, Combination
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Yonsei Medical Journal
Year:
2018
Type:
Article