Expression of exosomal miR-122 in patients with hepatitis C and its clinical function / 安徽医科大学学报

ABSTRACT

Objective To investigate the expression and the clinical function of exosomal miR-122 in patients with hepatitis C (HCV). Methods Forty HCV patients (28 HCV-1b and 12 non-HCV-1b) were enrolled in this study, serum and exosomal miR-122 and other conventional biomarkers reflecting liver function were measured.20healthy subjects were enrolled as control.ResultsThe expressions of exosomal miR-122 in HCV-1b and nonHCV-1b groups were higher than that in healthy group, but the former was slightly higher than the latter.Exosomal miR-122 in HCV group was weakly negatively related to AST and ALT levels.The expression of exosomal miR-122was consistent with that of serum miR-122.Besides, the serum miR-122 in sustained virological response (SVR) group was higher than that in non-sustained virological response (NR) group (P＜0.05), but statistical difference of exosomal miR-122 between SVR and NR groups was not found. Conclusion In HCV patients, exosomal miR-122 may be useful in evaluating hepatic impairment, but it cannot be used to evaluate the therapeutic effect.