Clinical significance of serum ferritin detection in myelodysplastic syndromes / 白血病·淋巴瘤

ABSTRACT

Objective To investigate the clinical significance of serum ferritin (SF) detection in myelodysplastic syndromes (MDS).Methods A total of 42 cases of MDS without blood transfusion who were admitted to General Hospital of Huainan Eastern Hospital Group from January 2010 to July 2017 were collected.There were 27 males and 15 females,aged 46-90 years old with a median age of 72 years old.In 42 cases of MDS,10 cases had refractory anemia (RA),4 cases had refractory anemia with ring increased iron bead young cell (RARS),8 cases had refractory blood cells decreased with more dysplasia (RCMD),and 20 cases had refractory anemia with primitive cells increased (RAEB).According to the International Prognostic Scoring System,22 cases had low risk,and 20 cases had high risk.At the same time,40 healthy checkers were chosen as healthy control group.SF levels were measured and compared between the MDS patients and healthy controls.Results The SF level in the MDS group was significantly higher than that in the healthy control group [(479±267) ng/ml vs.(153±56) ng/ml],and the difference was statistically significant (t =7.379,P ＜ 0.05).The difference in SF levels among the patients with different subtypes of MDS was statistically significant (F =4.81,P =0.006).Among them,the RA group had the lowest SF level,while the RAEB group had the highest,and the difference between the two groups was statistically significant [(346±257) ng/ml vs.(818±443) ng/ml,P =0.005].The SF level in the low-risk group was lower than that in the high-risk group [(456±238) ng/ml vs.(788±467) ng/ml],and the difference was statistically significant (t =2.867,P =0.008).Conclusion Patients with MDS show a significant increase in SF level,and high-risk patients are associated with iron overload,and SF may be an auxiliary indicator for judging the prognosis of MDS.