Fasting serum C-peptide is useful for initial classification of diabetes mellitus in children and adolescents
Annals of Pediatric Endocrinology & Metabolism
;
: 80-85, 2014.
Article
in English
| WPRIM
| ID: wpr-7428
ABSTRACT
PURPOSE:
With rising obesity rates in children, it is increasingly difficult to differentiate between type 1 and type 2 diabetes mellitus (T1DM, T2DM) on clinical grounds alone. Using C-peptide as a method of classifying diabetes mellitus (DM) has been suggested. This study aimed to find a correlation between fasting C-peptide level and DM types in children and adolescents.METHODS:
A total of 223 diabetic children, newly diagnosed at 5 hospitals between January 2001 and December 2012, were enrolled in this study. Initial DM classification was based on clinical and laboratory data including fasting C-peptide at diagnosis; final classification was based on additional data (pancreatic autoantibodies, human leukocyte antigen type, and clinical course).RESULTS:
Of 223 diabetic children, 140 were diagnosed with T1DM (62.8%) and the remaining 83 with T2DM (37.2%). The mean serum C-peptide level was significantly lower in children with T1DM (0.80 ng/mL) than in children with T2DM (3.91 ng/mL). Among 223 children, 54 had a serum C-peptide level 3.0 ng/mL; 48 of them (97.9%) were diagnosed with T2DM.CONCLUSION:
In this study, we found that if the C-peptide level was 3.0 ng/mL, a T1DM diagnosis is unlikely. This finding suggests that serum fasting C-peptide level is useful for classifying DM type at the time of diagnosis in youth.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
C-Peptide
/
Fasting
/
Classification
/
Diabetes Mellitus
/
Diabetes Mellitus, Type 2
/
Diagnosis
/
Leukocytes
/
Obesity
Type of study:
Diagnostic study
Limits:
Adolescent
/
Child
/
Humans
Language:
English
Journal:
Annals of Pediatric Endocrinology & Metabolism
Year:
2014
Type:
Article
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