Immunoreceptor NKG2D and its ligand-mediated cellular immunity and its relationship with diseases / 国际儿科学杂志

ABSTRACT

Natural killer (NK) cells play an important role in host defense.NKG2D is expressed as a homodimer on the surface of NK cells and is an important lymphocyte activating receptor.NKG2D ligands are negatively or poorly expressed on the surface of normal cells,but when the cells are in a state of oxidative stress,malignant transformation,autoimmune or inflammatory stimulation,these ligands will be induced on the cell surface.The NKG2D receptor and its ligand-mediated cellular immune response play an important role in immune surveillance of tumor cells,and at the same time it is also closely related to certain autoimmune diseases.