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Expression and clinical significance of long non-coding RNA Linc00152, H19 and ROR in patients with esophageal cancer / 国际检验医学杂志
International Journal of Laboratory Medicine ; (12): 226-229,233, 2019.
Article in Chinese | WPRIM | ID: wpr-742894
ABSTRACT
Objective To explore the diagnostic values of long non-coding RNA (lncRNA) Linc00152, H19and ROR in esophageal cancer, and to investigate the relationship between the three and the clinicopathological features of esophageal cancer.Methods Totally 185cases of esophageal cancer diagnosed (case group) in our hospital from October 2016to December 2017, and 200healthy controls (control group) were recruited during the same period.The levels of lncRNA Linc00152, H19and ROR in the peripheral blood of subjects were detected by real-time quantitative PCR (RT-qPCR).The diagnostic values of plasma lncRNA Linc00152, H19and ROR expression in esophageal cancer and the relationship between them and the clinical and pathological features of esophageal cancer were analyzed.Results The levels of plasma lncRNA Linc00152, H19and ROR in case group were higher than those in control group, and the difference were statistically significant (P<0.05).When combined detection with plasma lncRNA Linc00152, H19, and ROR, the area under the curve (AUC) to distinguish esophageal cancer and healthy subjects was 0.977 (95%CI0.902-0.998, P<0.001), and the sensitivity was 90.6%, specificity was 83.3%.In addition, the expressions of lncRNA Linc00152, H19, and ROR in plasma of patients with esophageal cancer were significantly correlated with TNM stage, histology classification and differentiation degree of tumor (P<0.05), but were not related to gender, age, and tumor sites (P>0.05).Multivariate analysis showed that plasma lncRNA H19and ROR levels were both independent risk factors for esophageal cancer, which is of guiding significances for predicting the risk of esophageal cancer.Conclusion LncRNA Linc00152, H19and ROR have diagnostic values for esophageal cancer, and are significantly correlated with the differentiation degree, histology classification, and TNM stage of esophageal carcinoma.Plasma lncRNA H19and ROR have potential application value in predicting the risk of esophageal cancer.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: International Journal of Laboratory Medicine Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: International Journal of Laboratory Medicine Year: 2019 Type: Article