Advances in research on circular RNAs / 国际检验医学杂志

ABSTRACT

Circular RNAs (circRNAs) are universal and diverse endogenous non-coding RNAs which widely found in eukaryotic cells.They form covalently closed, continuous and stable ring structure, which play the role of microRNA (miRNA) molecular sponge and regulate gene transcription and selective splicing.These molecules offer new potential opportunities for therapeutic intervention and serve as biomarkers for diagnosis.This paper provides an overview of the formation, function and detection methods of circRNAs, and summarizes the biological role of circRNAs in the development and progression of diseases such as nervous system diseases, cardiovascular diseases, cancer and infection, and provides evidence for the potential use of circRNAs in diagnosis.