Study on oxidative and antioxidation imbalance of hashimoto′s thyroiditis patients / 国际检验医学杂志

ABSTRACT

Objective To detect the oxidative and anti-oxidative imbalance of Hashimoto′s thyroiditis (HT) with specific thyroid function through specific serum.Methods 41 patients with normal thyroid function of Hashimoto′s thyroiditis and 43 healthy controls were enrolled in our hospital from May 2016 to May2017.Through specific serum tests, such as derived active oxygen metabolism (d-ROM) and biological antioxidant potential (BAP), advanced glycation end products (AGE) and advanced oxidized protein products (AOPP) were used to assess oxidative stress.Results The levels of d-ROM and AGEs were significantly increased (P＜0.05) and BAP was significantly lower in both groups compared with HT patients (P＜0.001).In univariate analysis, serum TSH, TgAb and TPOAb were significantly associated with d-ROMs (P＜0.05).HDL-C, serum TSH, TgAb and TPOAb were significantly associated with BAP (P＜0.05).Total cholesterol and LDL-C were significantly associated with AGEs (P＜0.05).Multivariate analysis showed that serum TPOAb was a predictor of d-ROMs (P＜0.001), BAP (P＜0.001), and AGEs (P=0.003).In addition, HDLC was also an independent predictor of BAP levels (P=0.012, R2=2.354, 95％CI1.191-5.433).While LDL-C was an independent predictor of AGEs (P =0.004, R2=1.102, 95％CI0.915-1.253).Conclusion HT patients increased oxidant, antioxidants decreased.And AGEs were significantly higher, AGEs levels can be used as a new HT oxidative stress a reliable biomarker.