Effect of HAART on CD4+T cell and viral load in children with AIDS combined with HBV/HCV infection / 国际检验医学杂志

ABSTRACT

Objective To investigate the effect of high performance antiretroviral therapy on CD4+T cells, viral load and liver function in children with AIDS combined with HBV/HCV infection.Methods The simple HIV from April 2014to April 2015in our hospital infection in 88cases were divided into group A, 8cases of HIV patients with HBV infection was divided into B group, and 23cases of HIV patients with HCV infection was divided into C group, three groups were all treated with HAART, after about two years treatment time, before and after treatment of liver function, viral load and CD4+T cell changes between the three groups were compared.Results Before treatment, the total of three groups of children with abnormal liver function was 29cases (24.79％) , and the three groups were not statistically significant (P>0.05) .After treatment, the total of three groups of children with abnormal liver function were 82 (70.09％) , and the difference between the three groups was statistically significant (P<0.05) .Before treatment, there was no significant difference in the levels of AIT, AST and TBIL between the three groups (P>0.05) .After treatment, the levels of AIT, AST and TBIL in the three groups increased significantly (P<0.05) .The data between the three groups were not statistically significant (P>0.05) .Before treatment, there was no significant difference between the three groups of children with CD4+T cells and viral load (P>0.05);after treatment, the three groups of patients with CD4+T (P<0.05) cells increased, HIVRNA decreased significantly (P<0.05) , the three groups had no statistically significant difference between the two groups of patients (P>0.05) .Conclusion High-efficiency antiretroviral treatment in children with AIDS complicated with HBV/HCV infection, there are different differences in liver function of patients, after treatment can significantly increase the level of CD4+T cells, reduce viral load, AIDS combined with HBV/HCV infected children have different differences, the liver function should be paid close attention in clinical application.