Study on the expression of serum NO and Gal-9 and its correlation with apoptosis in elderly patients with cervical cancer / 国际检验医学杂志

ABSTRACT

Objective To investigate and analyze the expression of serum NO and Gal-9and its correlation with apoptosis in elderly patients with cervical cancer.Methods 76cases of elderly patients with cervical cancer in our hospital as the cervical cancer group, 50cases of cervical epithelial dysplasia of uterus in elderly (CIN) were taken as CIN group and 50healthy elderly people as healthy controls were detected by flow cytometry in three subjects tissue apoptosis index (AI) and the detection of serum NO and Gal-9levels in three groups of subjects, difference analysis and correlation of the indicators of the three groups of subjects, and analyze the relationship between the serum of patients with cervical cancer NO, Gal-9levels and pathological features.Results There was a significant difference in the tissue apoptosis index (AI) between the three groups (P<0.05) , and the AIindex in the cervical cancer group was significantly higher than that in the healthy control group (P<0.05) , but it was significantly lower than that in the CIN group (P<0.05) .The serum NO and Gal-9levels of the three groups were statistically different (P<0.05) , and the levels of NO and Gal-9in the cervical cancer group were significantly higher than those in the healthy control group and CIN group (P<0.05) .The serum levels of NO and Gal-9in patients with cervical cancer were positively correlated with the value of AI (r=0.813, 0.872, P<0.05) .The serum NO and Gal-9levels in patients with stageⅢandⅣof cervical cancer were significantly higher than those inⅠandⅡpatients (P<0.05) .The serum Gal-9level in patients with poorly differentiated tumors was significantly higher than that in patients with high or intermediate differentiation (P<0.05) .Conclusion Serum NO and Gal-9play an important role in the occurrence and development of cervical cancer in elderly patients, and play a certain role in the apoptosis of cervical cancer tissues.The specific mechanisms of their effects need further research and analysis.