Expression and clinical significance of serum CysC and CTRP9 levels in patients with essential hypertension with different blood pressure grades / 国际检验医学杂志

ABSTRACT

Objective To explore the expression and clinical significance of serum cystatin C (CysC) and complement-C1q/TNF-related protein 9 (CTRP9) levels in patients with essential hypertension with with different blood pressure grades.Methods 80patients with essential hypertension who were treated in our hospital were selected as the observation group.According to the difference of blood pressure level, the patients in the observation group were divided into 1grade hypertension group (24cases) , 2grade hypertension group (36cases) and 3grade hypertension group (20cases) .In addition, 50healthy volunteers who were received physical examination in our hospital were selected as the control group.The levels of CysC, CTRP9, ankle brachial pulse wave velocity (baPWV) , carotid intima media thickness (cIMT) , mean arterial pressure (MAP) , high-density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were detected in all subjects.The correlation between CysC, CTRP9and baPWV, cIMT, MAP, HDL-C and LDL-C in patients with essential hypertension was analyzed.Results The level of CysC was positively correlated with baPWV, cIMT and MAP (r=0.556, 0.488, 0.369, P<0.05) , and the level of CTRP9was negatively correlated with baPWV, cIMT, MAP and LDL-C (r=-0.437, -0.397, -0.296, -0.203, P<0.05) .Conclusion The expression level of CysC and CTRP9in the serum of patients with essential hypertension is related to blood pressure classification and atherosclerosis related indexes, serum levels of CysC and CTRP9can be used to assess blood pressure and atherosclerosis.