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Correlation between cerebral atherosclerotic stenosis and early neurological deterioration in patients with acute large artery atherosclerotic stroke / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases ; (12): 6-11, 2019.
Article in Chinese | WPRIM | ID: wpr-742961
ABSTRACT
Objective To investigate the correlation between the distnioution of cerebral atherosclerotic stenosis and early neurologic deterioration (END) in patients with acute large artery atherosclerotic stroke.Methods Patients with acute large artery atherosclerotic stroke admitted to the Department of Neurology,the Second Affiliated Hospital of Anhui Medical University from March 2017 to May 2018 were enrolled retrospectively.END was defined as the National Institutes of Health Stroke Scale (NIHSS) score increased by 2 from the baseline within 72 h of admission,or the NIHSS consciousness level score increased by 1,or the NIHSS motor score increased by 1,or having any new neurological deficit.According to whether the patients had END or not,they were divided into END group and non-END group.According to cerebral artery stenosis (stenosis degree > 50%) identified by head and neck CT angiography,magnetic resonance angiography or digital subtraction angiography,they were divided into single artery stenosis group and multiple artery stenosis group.Multivariable logistic regression analysis was used to analyze the independent risk factors for END.Results A total of 371 patients were enrolled in the study,of which 92 (24.8%) had END.In the single artery stenosis group,the incidence of END varies with the distribution of vessel stenosisanterior cerebral artery (2.3%),middle cerebral artery (54.4%),posterior cerebral artery (9.1%),basilar artery (4.5%),intracranial internal carotid artery (11.4%),intracranial vertebral artery (6.8%),extracranial internal carotid artery (6.8%),and extracranial vertebral artery (4.5%).The incidence of middle cerebral artery stenosis was significantly higher in the END group than that in the non-END group (54.5% vs.21.2%;x2=17.615,P < 0.001).In the multiple artery stenosis group,the incidence of END was the highest in patients with only intracranial stenosis (66.7%),followed by patients with intracranial and extracranial stenosis (29.2%),and patients with only extracranial stenosis (4.2%).The incidence of only intracranial multi-artery stenosis was significantly higher in the END group than that in the non-END group (66.7% vs.47.6%;x2 =5.262,P =0.022).Multivariate logistic regression analysis showed that middle cerebral artery stenosis (odds ratio,1.805,95% confidence interval 1.217-2.676;P=0.003) was an independent risk factor for END.Conclusions END was associated with the distribution of cerebral atherosclerotic stenosis in patients with acute large artery atherosclerotic stroke.The middle cerebral artery stenosis was an independent risk factor for END.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: International Journal of Cerebrovascular Diseases Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: International Journal of Cerebrovascular Diseases Year: 2019 Type: Article