Role of microRNA in ischemic brain injury / 国际脑血管病杂志

ABSTRACT

MicroRNAs (miRNAs) are a class of short non-coding single-stranded RNAs.They can regulate gene expression at the post-transcriptional level by binding to the T-untranslated region of the target gene mRNA and participate in the regulation of almost all biological processes.Recent studies have shown that MiRNAs are widely involved in a variety of pathophysiological processes in ischemic brain injury,such as excitotoxicity,oxidative stress,inflammation,apoptosis,and cerebral edema,suggesting that they may serve as a biomarker for ischemic stroke,assisting early diagnosis and outcome assessment,and becoming a drug treatment target.