Application of chitosan in delivery of active natural products / 国际药学研究杂志

ABSTRACT

Chitosan,a natural polysaccharide,has attracted increasing attention as an excellent carrier for drug delivery.The advantages of chitosan include its good biocompatibility,biodegradability and non-toxicity.Polyphenol,flavone,coumarin,terpenes,alkaloids are important active natural products for disease treatment.Curcumin,paclitaxel,resveratrol,podophyllotoxin,vincristine,cannabidiol,triptolide are all remarkable molecules of bioactive natural products.However,most of them cannot be made into appropriate formulations due to their poor stability.It is imperative to select an appropriate drug delivery system to improve the stability of natural products.This review summarizes the recent progress related to chitosanbased drug delivery system for natural product,involving nanoparticles,hydrogels,microspheres,films,nanofibers,sponges and liposomes.In addition,this review describes the characteristics of chitosan in promoting wound healing,inhibiting bacterial growth,treating tumors and osteoarthritis.It seems that chitosan will be a promising and important excipient for novel formulations of bioactive natural products.