Predictive biomarkers of efficacy to PD-1/PD-L1 inhibitors / 国际肿瘤学杂志

ABSTRACT

With the development of tumor precise immunotherapy,it is a hot topic to find biomarkers to predict the response ability of programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1).So far,many predictors,such as the PD-L1 expression in tumor tissue,tumor-infiltrating lymphocyte,tumor mutational burden,serum markers and radiographic markers,have shown predictive value in the process of anti-PD-1/PD-L1 immunotherapy.But each predictor has its limitations.