Prognostic Impact of Baseline High-Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention Based on Body Mass Index
Korean Circulation Journal
;
: 164-172, 2012.
Article
in English
| WPRIM
| ID: wpr-74326
ABSTRACT
BACKGROUND AND OBJECTIVES:
Serum high sensitivity C-reactive protein (hs-CRP) is a marker of inflammation and may lead to the development of atherosclerosis, adversely affecting mortality. The aim of this study was to evaluate the relationship between baseline hs-CRP level and 12-month clinical outcomes in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) according to their body mass index (BMI) status. SUBJECTS ANDMETHODS:
Using data from the Korea Acute Myocardial Infarction Registry from November 2005 to September 2008, a total of 8174 consecutive AMI patients were studied. Cox proportional hazard model revealed that higher baseline levels of hs-CRP was associated with 12-month all-cause mortality (p=0.045). To further understand this association, patients were divided into 3 groups based on their body mass index 1) overweight/obese, 2) normal weight, and 3) underweight patients. Then each group was stratified into quartiles based on their hs-CRP.RESULTS:
In overweight/obese patients, Cox model showed significant association of hs-CRP with 12-month mortality when adjusted for age and gender (p or =4.08 mg/dL) in overweight/obese AMI patients showed significant association with 12-month all-cause mortality independent of other prognostic markers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thinness
/
C-Reactive Protein
/
Body Mass Index
/
Proportional Hazards Models
/
Atherosclerosis
/
Overweight
/
Percutaneous Coronary Intervention
/
Inflammation
/
Korea
/
Myocardial Infarction
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Korean Circulation Journal
Year:
2012
Type:
Article
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