Correlation analysis of serum thyroglobulin antibody with the risk of thyroid cancer in patients with thyroid nodule / 中华内分泌外科杂志

ABSTRACT

Objective To study the association between serum thyroglobulin antibody(TgAb) and the risk of thyroid cancer (TC) in patients with thyroid nodule (TN).Methods The determination of benign and malignant TN was based on routine pathological biopsy of postoperative thyroid tissues.Serum TgAb level of 1257 patients with TN undergoing surgery from 1st Sep.2015 to 31st Dec.2016 was determined by electrochemiluminescence immunoassay.A retrospective cohort analysis was performed.The correlation between the serum TgAb level and the benign or malignant rate of thyroid nodule was determined by Pearson Chi-square test.Results Among the 1257 patients,there were 196 patients whose TgAb level was high.Among these 196 patients,there were 94 patients with benign TN,with the benign rate of 47.96％ and there were 102 patients with malignant TN,with the malignant rate of 52.04％.There were also 1061 patients whose TgAb level was normal,among these 1061 patients,there were 654 patients with benign TN,with the benign rate of 61.64％ and there were 407 patients with malignant TN,with the malignant rate of 38.36％.For papillary thyroid carcinoma(PTC)patients,x2=23.101 9,OR=1.7218,the 95％ CI of OR was(1.382 9,2.375 4).For follicular thyroid carcinoma(FTC) patients,x2=0.287 5,P＞0.01.For medullary thyroid carcinoma (MTC) patients,P=0.048 9＞0.01.Conclusions Among patients with TN,PTC rate of the patients whose serun TgAb level is high is higher than patients whose serum TgAb level is normal.But among the patients with TN,we do not think that FTC and MTC rate of patients whose serun TgAb level is high is higher than patients whose serum TgAb level is normal.