Efficacy and safety of microwave ablation for benign thyroid nodules: a Meta-analysis / 中华内分泌外科杂志

ABSTRACT

Objective To evaluate the efficacy and safety of microwave ablation in treatment of benign thyroid nodules by a meta-analysis.Methods A database searching was performed on the Pubmed (Medline),CochraneLibrary,Embase,China National Knowledge Infrastructure(CNKI),wanfang database,biomedical literature database (Sinomed) and VIP database.Randomized controlled studies of microwave ablation for benign thyroid nodules were selected and analyzed.Documents were screened in accordance with the inclusion and exclusion criteria.Data analysis was performed by using Revman5.3 software.Results Twelve studies matched the selection criteria,which involved 1221 patients.The results showed that microwave ablation was superior to traditional surgery in the following aspectsthe time of operation [MD=-50.78,95％ CI=(-58.20,-43.36),P＜0.01,I2=97％],the amount of blood loss[MD=-23.21,95％ CI=(-27.18,-19.23),P＜0.01,I2=99％],the time of hospitalization [MD=-3.39,95％ CI=(-4.08,-2.71),P＜0.01,I2=98％],the changes of CRP,IL-6,TNF-alpha in 12 h,24 h or 48 h after operation,the changes in the level of FT3 and FT4 in 1 month and 3 months after operation,and the incidence of surgical complications [MD=0.20,95％ CI=(0.13,0.32),P＜0.01,I2=0％],P＜0.01 respectively.Conclusions Microwave ablation has many advantages,such as small trauma,beautiful appearance,quick recovery,little influence on thyroid function and fewer operative complications.It is safe and reliable in clinical application.