Parcellationofthethalamusbasedongraymattervolumecovarianceinhealthymales / 实用放射学杂志
Journal of Practical Radiology
;
(12): 345-348, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-743533
ABSTRACT
Objective Toexplorethefeasibilityandaccuracyofsegmentationofthethalamusinhealthymaleswithgraymatter volumecovariance(GMVC)covariancepattern.Methods T1 3DstructuralMRIdatawerecollectedin103 maleparticipants [age from19to50y,mean=(35.5±7.7)y,educationfrom6to16y,mean=(10.5±2.3)y].AfterpreprocessedbyCAT12softwarewith standardprocedure (registration,segmentation,modulationandsmooth),thevoxelGwisebilateralthalamusgray mattervolume (GMV)andthewholebrain’svoxelGwiseGMVdatawereextractedtocalculatethecovariancematrixofallparticipants.ExtendedKGmeans clusteringalgorithm wasappliedtosegmentthalamusintosubGareas.RandomsubGsamplingandcrossingGvalidationtechniquewere usedtogenerate100subGdatasetsandverifythesimilarityindex.Cramers’V (CV)wascalculatedandtheKrelevanttothehighest meanofCV wasdeterminedastheoptimalnumberofsubGareasforthalamus.Results Theleftandrightthalamuswereoptimally segmentedinto11and13subGareasbyGMVcovariancepattern.BoththeleftandrightthalamuscomprisesAnteriorNuclear,ventral anteriornucleus,lateraldorsalnucleus,lateralposteriornucleus,ventrallateralnucleus,ventralposteriormedialnucleus,ventralposterior lateralnucleus,midlinenucleus,medialdorsalnucleusandpulvinar.Additionally,fortherightthalamus,anteriornucleargroupwas dividedinto2parts,dorsalpartandventralpart,andthemidlinenucleusintomedialpartandlateralpart.Thelateraldorsalandlateral posteriornucleusweremergedintolateralnucleargroup.Fortheleftthalamus,thelateralposteriornucleuswasfurtherdividedinto2 parts,anteriorpartandposteriorpart.Thesegmentationresultswerealmostalinewiththeanatomical14partitionofthalamus.Conclusion TheparcellationbasedonGMVCcovariancepatternisaneffectiveandreliabletoolforsegmentationofbraingraymatternucleus. Ourfindingsprovideexperimentbasisforthalamusfunctionalandstructuralstudyinthefutureandoptimaltreatmenttargetforneurosurgery anddeepbrainstimulustherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Practical Radiology
Year:
2019
Type:
Article
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