The expression and significance of MAPK8 gene in oral squamous cell carcinoma / 实用口腔医学杂志

ABSTRACT

Objective: To study the the expression and significance of MAPK8 gene in oral squamous cell carcinoma (OSCC) .Methods: 17 cases of oral normal tissues and 42 of OSCC tissues were collected. The relative expression of MAPK8 mRNA was detected by Real-Time PCR, the expression of MAPK8 protein was detected by immunohistochemical SP method. Results: Over expression of MAPK8 mRNA and protein was observed in OSCC (P ＜ 0. 05), the expression was correlated with the differentiation (P ＜ 0. 05) and clinical stage (P ＜ 0. 05) of the lesion, but not with the age (P＞ 0. 05) and gender (P＞ 0. 05) . Conclusion: MAPK8 gene may play an important role in the development of OSCC.