Difficulties in diagnosis and treatment of pediatric severe adenovirus pneumonia / 中国小儿急救医学

ABSTRACT

Adenovirus is a common cause of respiratory infection in children.Severe adenovirus pneumonia often occurs in infants or immunocompetent persons.The high incidence age is from 6 months to 2 years old.The clinical symptoms are hyperpyrexia,pale face,poor mental state,respiratory distress or wheezing,and fever may last 4-7days or longer.Severe extra-pulmonary complications are common especially in cardiovascular and hepatic dysfunction.Symptoms are similar to severe bacterial infections,but antibiotics is not effective,and mortality is high.X-ray imaging in acute phase is characterized by asymmetric exudation of lung,partial exudation fusion and interstitial emphysema.Rapid identification of adenovirus infection remains a difficult problem.Multiple nested polymerase chain reaction is helpful.Appropriate oxygen therapy and organ support are the main therapeutic strategies.Extracorporeal membrane oxygenation needs to be further explored as salvage therapy.