Clinical analysis of nifedipine combined with irbesartan in the treatment of diabetes mellitus with hypertension / 中国基层医药

ABSTRACT

Objective To investigate the clinical effect of nifedipine combined with irbesartan in the treatment of diabetes mellitus with hypertension.Methods From August 2015 to January 2017,66 diabetes mellitus patients with hypertension in the First People's Hospital of Yongkang were selected in the study and randomly divided into control group and observation group,with 33 cases in each group.The control group was treated with nifedipine,and the observation group was treated with nifedipine combined with irbesartan for 2 months.The changes of blood pressure,blood sugar and adverse reactions of the two groups were observed.Results After treatment,the diastolic blood pressure,systolic blood pressure,postprandial blood glucose,fasting blood glucose,psychological score,physiological score,social relation score,substance life score in the observation group were (72.71 ± 4.04)mmHg,(121.78 ± 4.22) mmHg,(7.55 ± 1.26) mmol/L,(5.25 ± 0.79) mmol/L,(88.22 ± 4.31) points,(86.75 ± 3.82) points,(82.38 ± 3.23) points,(81.85 ± 2.79) points,respectively,which were better than those of the control group [(88.95 ± 3.71) mmHg,(138.44 ± 5.25) mmHg,(11.50 ± 2.12) mmol/L,(7.33 ± 0.70) mmol/L,(74.58 ± 3.93) points,(73.71 ± 4.04) points,(74.62 ± 3.93) points,(75.76 ± 3.32) points],the differences were statistically significant(t =15.94,13.32,8.63,10.61,13.43,13.47,8.76,8.07,all P ＜ 0.05).The incidence rate of adverse events was 18.18％ in the control group,which in the observation group was 12.12％,there was no statistically significant difference between the two groups(P ＞ 0.05).Condusion Nifedipine combined with irbesartan is superior to nifedipine in the treatment of diabetes mellitus with hypertension.